ESR2 and infection: Data analysis showed that invasive isolates decreased the level of ERβ to a greater extent than the carried isolates (column 2 vs. 3, ***P < 0.001) (Figure 1C), while the level of ERβ showed no significant difference after carried isolates infection compared with the CTR (column 1 vs. 2, P > 0.05) (Figure 1C).