An MECP2 genotype-related distribution of scoliosis frequency was observed (chi-square 21.818, DF = 8, p = 0.0053) with the highest frequency in patients with RTT with non-hotspot-type mutations (24.2%), C-terminal deletions (18.2%), R255X (12.1%), R270X (12.1%), and T158M (12.1%). Here, MECP2 is linked to scoliosis.