DDIT3 and asthma: However, the ability of R2-Pep to reduce CHOP expression to normal physiological levels offers the opportunity to prevent CHOP-mediated cell death in pathological conditions primary unrelated to GABAB receptors such as diabetes (Oyadomari et al., 2002), asthma (Wang et al., 2017) or Alzheimer’s (Prasanthi et al., 2011).