IL1B and obesity due to melanocortin 4 receptor deficiency: Subsequently, the functional enrichment analysis of the 233 significantly expressed inflammatory genes showed that the most significant biological annotations were inflammatory response, cytokine production, innate immune response, macrophage activation, TLR signaling pathway, type I and II interferon production, JAK-STAT signaling pathway, NF-κB signaling pathway, TNF signaling pathway, blood coagulation, oncostatin M signaling pathway, IL-1 and megakaryocytes in obesity, and the NLRP3 inflammasome complex (Table 1).