Some examples were already described in the cancer field, where the tumor-derived sEVs were demonstrated to be enriched in certain miRNAs that could act as tumor markers (Kumar et al., 2015), or in circulating sEVs derived from glioblastoma patients, which have showed increased levels of Epidermal Growth Factor Receptor (EGFR)-vIII mRNA (Skog et al., 2008). Here, COX8A is linked to neoplasm.