In addition, an in vivo study using genetically engineered EVs carrying the suicide gene for cytosine deaminase (CD) fused to uracil phosphoribosyltransferase (UPRT) demonstrated a reduction in the tumor growth in the glioblastoma mice model after treatment with the CD-UPRT-enriched EVs (Erkan et al., 2017). This evidence concerns the gene UPRT and neoplasm.