Other examples related with the central nervous system (CNS) disorders include the AT270 phospho-tau, a biomarker for Alzheimer’s disease (AD), detected in sEVs collected from the cerebrospinal fluid (CSF) of patients with mild disease (Saman et al., 2012), and syntenin one that was found elevated in the circulating sEVs isolated from the serum of Parkinson’s disease (PD) patients (Tomlinson et al., 2015). This evidence concerns the gene MAPT and Parkinson disease.