• Inhibition of GLUT4 membrane translocation. • Induction of the serine phosphorylation of insulin substrate-1, leading to insulin resistance. • Suppression of the lipoprotein lipase activity. • Inhibitor of adipocyte differentiation. • Suppression of genes involved in uptake and storage of non-esterified fatty acids and glucose. The gene discussed is LPL; the disease is Insulin resistance.