JAG1 and Alagille syndrome: In addition to the drosophila studies, missense mutant of Jagged1 induces Nodder (Hansson et al., 2010) and Slalom (Tsai et al., 2001) in mice and, in Human, mutations in DSL and EGF-like repeats domains of JAG1 cause Alagille syndrome and mutations in only EGF-like repeats cause familial tetralogy of Fallot (Eldadah et al., 2001).