Next-generation sequencing of germline DNA in 2,160 early-onset BC and 1,199 patients with ovarian cancer revealed nearly 2% of patients carry a very rare missense variant in BRIP1, which is 3-fold higher than the frequency of all rare BRIP1 missense alleles reported in more than 60,000 individuals of the general population [56]. The gene discussed is BRIP1; the disease is breast cancer.