KLF6 and hepatocellular carcinoma: KLF6 plays an inhibitory role in cell proliferation in various normal and tumor cells.25,35 In hepatoma cell lines, KLF6 overexpression inhibits cell proliferation, migration, and angiogenesis.36Klf6 overexpression induced the inhibition of iMDP-3 cell proliferation and cell cycle arrest, whereas knocking down Klf6 promoted cell proliferation and progression at G1-S transition (Figs. 4j’, 5j’).