Many somatic mutations in MLKL are also found in malignant melanoma patients, of which many are located in the pseudokinase domain (D390N, F469Y, P189L, S454F, L377F, G330E, D296N, P260L, E250K, F398I, L291P, E351K) and a few in the 4-helical bundle domain (G74E, E70K, P41A) (COSMIC) [43, 45, 46]. The gene discussed is MLKL; the disease is melanoma.