Among 13 commonly downregulated genes in four patients (Fig. 8F and Supplementary Table S4), 10 genes (FMO2 [45], ZBTB16 [46], FCN3 [47], TCF21 [48], SFTPA1B [49], HPGD [50], SOSTDC1 [51], TMEM100 [52], GDF10 [53], and WIF1 [54]) have been reported as tumor suppressors in lung cancer. The gene discussed is SOSTDC1; the disease is lung cancer.