The first study to specifically evaluate gene expression in DLPFC from depressed suicides (MDD-S, N = 21), depressed non-suicides (MDD-NS, N = 9) and controls (N = 29) using RNA-Seq found significant alterations of the spermidine/spermine N1-Acetyltransferase1 (SAT1) gene in both MDD groups [16]. This evidence concerns the gene SAT1 and major depressive disorder.