AAV-shRNA-Cldn5 injected mice with focal downregulation of claudin-5 in the dorsal hippocampus, subjected to seizures by intraperitoneal (i.p.)injection of a mildly convulsant dose of kainic acid, performed worse in the novel object recognition task and had reduced distance travelled and centre zone entries in the open field test, readouts of cognitive function and anxiety respectively (Fig. 2m, n). The gene discussed is CLDN5; the disease is Anxiety.