Following kainic acid injection, Cldn5 heterozygous mice had shorter latency to seizure onset (Fig. 3g), while 100% (5/5) of heterozygous mice entered status epilepticus, defined as more than 5 min of continuous seizures, compared to 16% (1/6) of WT mice (Fig. 3h). The gene discussed is CLDN5; the disease is status epilepticus.