Mannoor et al. pointed out that in non-small cell lung cancer (NSCLC), the expression of SNORD1C in ALDH + tumor cells was much higher than that in ALDH- tumor cells, and the ALDH + tumor cell group showed a poor prognosis [15], which not only revealed the promoting effect of SNORD1C in malignant tumors, but also suggested that SNORD1C may be closely related to tumor cell self-renewal and cancer recurrence. This evidence concerns the gene LDHA and non-small cell lung carcinoma.