Lachnospiraceae bacterium 7_1_58FAA has a clear connection with L-glutamate degradation V. Note that L-glutamate dehydrogenase deficiency leads to D-2-hydroxyglutarate dehydrogenase deficiency [87], and a CRC specific pathway through D-2-hydroxyglutarate can drive epithelial-mesenchymal transition and induce CRC progression [88]. Here, D2HGDH is linked to colorectal carcinoma.