Lachnospiraceae bacterium 7_1_58FAA has a clear connection with L-glutamate degradation V. Note that L-glutamate dehydrogenase deficiency leads to D-2-hydroxyglutarate dehydrogenase deficiency [87], and a CRC specific pathway through D-2-hydroxyglutarate can drive epithelial-mesenchymal transition and induce CRC progression [88]. The gene discussed is D2HGDH; the disease is hyperinsulinemic hypoglycemia, familial, 4.