Xie et al. demonstrated that in vitro cultured macrophages treated with endometrial homogenates from women with endometriosis had significantly increased SIRPα expression, not observed when the macrophages were treated with homogenates of endometrium from women without disease [29], also suggesting that signals from eutopic endometrium affect the phagocytic capacity of macrophages. This evidence concerns the gene SIRPA and endometriosis.