Moreover, the proportion of CML patients with hypermethylation of promoter CpG dinucleotides of DAPK1, RIZ1, P16INK4A, RASSF1A and p14ARFARF genes was significantly more in advanced disease (AP and BC) stages in comparison to early CML (CP) disease subjects. This evidence concerns the gene CDKN2A and chronic myelogenous leukemia, BCR-ABL1 positive.