In this study, we found that APOA1-overexpressing (OE) and normal control (NC) SiHa and Caski cervical squamous carcinoma cells showed smaller differences in the change of clones after administration of chemotherapy (p < 0.05), indicating that overexpression of APOA1 induced resistance to carbopaltin chemotherapy in cervical cancer cells and reduced the chemotherapy-induced reduction of cell cloning. The gene discussed is APOA1; the disease is cervical cancer.