We identified and quantitatively validated the proteins downstream of APOA1 by PRM, which indicated that APOA1 may exert its carboplatin chemoresistance effects in cervical squamous carcinoma by 1) promoting tumor growth, recurrence, and metastasis through TOP2A, CDKN2A, and APOE; 2) regulating the p38 MAPK signaling pathway through STAT1 to promote in tumor growth and metastasis; 3) regulating the PI3K signaling pathway through CD81, C3, and RAC1 to promote tumor progression; and 4) promoting metastasis through ALB, AFP, GC, LTF, SOD2, and NDRG1. Here, TOP2A is linked to neoplasm.