Mutations or aberrant expression of oncogenic TFs in tumor have been frequently demonstrated, such as SOX2 in esophageal squamous cancer (Watanabe et al. 2014), NKX2-1 in lung adenocarcinoma (Mollaoglu et al. 2018) and AR in prostate cancer (Culig and Santer 2014), however, their dysfunctional transcriptional regulations have been seldom studied, especially in gastric carcinogenesis. The gene discussed is NKX2-1; the disease is Familial prostate cancer.