Consistent with the modeling result that the negative regulation of TCEAL2 by CREB1 disappeared from normal to cancer, the expression of TCEAL2 was markedly decreased in GES-1/CREB1 and increased in GES-1/CREB1-siRNA compared with control group, while the expression of TCEAL2 in NCI-N87 kept stable between disturbed (CREB1 or CREB1-siRNA) and control (Fig. 3B). This evidence concerns the gene CREB1 and cancer.