SOX2 and Familial prostate cancer: Mutations or aberrant expression of oncogenic TFs in tumor have been frequently demonstrated, such as SOX2 in esophageal squamous cancer (Watanabe et al. 2014), NKX2-1 in lung adenocarcinoma (Mollaoglu et al. 2018) and AR in prostate cancer (Culig and Santer 2014), however, their dysfunctional transcriptional regulations have been seldom studied, especially in gastric carcinogenesis.