In order to confirm the effects of differential regulation by CREB1, we examined the changes in mRNA expression of the seven candidate dysregulated targets of CREB1, including TRIM15, TCEAL2, NHERF1, RBPMS2, FERMT2, FAM20C and MBNL1, after silencing and overexpressing CREB1 in immortalized gastric epithelial cell line GES-1 and GC cell line NCI-N87, respectively. The gene discussed is RBPMS2; the disease is gastric cancer.