According to the regulation efficacy data (Table 4), the positive regulation of TRIM15 and NHERF1 by CREB1 was reversed from normal to cancer; the negative regulations of TCEAL2, RBPMS2 and FAM20C by CREB1 disappeared; and the negative regulation of FERMT2 was reversed from normal to cancer. This evidence concerns the gene RBPMS2 and cancer.