CREB1 and cancer: In accordance with the modeling result that MBNL1 was only positively regulated by CREB1 in cancer, the expression of MBNL1 in GES-1 did not show any significant change between disturbed (CREB1 or CREB1-siRNA) and control, while it was significantly increased in NCI-N87/CREB1 and decreased in NCI-N87/CREB1-siRNA compared with control (Fig. 3B).