HMGCS2-OE in 34-weeks of HFD-induced NAFLD mice led to gradual reductions in body weight at 2- and 3-weeks post-virus injection compared to control (Figure 5E), which was mainly attributed to decreases in fat mass, not lean mass (Figure 5F,G). The gene discussed is HMGCS2; the disease is metabolic dysfunction-associated steatotic liver disease.