Moreover, as NAFLD pathogenesis has been associated with genes encoding mediators of lipid metabolism (i.e., PNPLA3, TM6SF2) [77,78], it would be interesting to examine a genetic link associated with ketogenic mediators (i.e., HMGCS2 and HMGCL). The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.