Not a singleton pregnancy; not Han ethnicity; fasting glucose ≥6.1 mmol/L and/or HbA1c >6.5% or diagnosed as diabetes before pregnancy; history of autoimmune disease, or currently use corticosteroids; hyperthyroidism or hypothyroidism; miscarried or induced labour before OGTT at 24–28 weeks; history of liver or renal insufficiency or CRP >10 mg/L; suspected familial hypertriglyceridemia; incomplete records of lipid profiles and/or FPG concentration. The gene discussed is CRP; the disease is autoimmune disease.