In addition to regulating downstream genes, lncRNA TUG1 can also directly bind protein as a regulator,22 thus affecting the development of liver cancer: TUG1 inhibits KLF2 transcription in HCC cells epigenetically by binding to polysulfide protein2 and recruiting it to Kruppel like factor 2 promoter region. This evidence concerns the gene KLF2 and hepatocellular carcinoma.