Consistent with results from our positive selection cell survival screens, Dox induction of gRNA-mediated OAS1 expression conferred a dramatic improvement in cell survival assessed at 72 hours post-infection in both A549-SunTag ACE2 and A549ΔSTAT1-SunTag ACE2 cultures; DoxOff cultures and cultures transduced with NTG were readily eliminated by infection (Fig 4B). The gene discussed is OAS1; the disease is infection.