Furthermore, the two oncogenes upregulate matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) and induce epithelial-mesenchymal transition (EMT) transcription factors in cervical cancer and head and neck squamous cell carcinoma (HNSCC) [7, 8]. Here, MMP2 is linked to head and neck squamous cell carcinoma.