Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP) are incurable neurodegenerative disorders that share some common pathological hallmarks, such as synapse loss and the presence of intraneuronal neurofibrillary tangles (NFTs) composed of hyperphosphorylated microtubule-associated protein tau (MAPT or TAU) [1, 2]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.