In AD modules, we found WNT3 and PLCG2 in M1 (synapse signaling, enriched mainly in glutamatergic neurons), ABCA1, CR1, DOC2A and PTK2B in M2 (synapse signaling, enriched in glutamatergic neurons), CSTH and EGFR in M4 (cellular response to growth factors, enriched in astrocytes), and HLA-DRA, INPP5D, TREM1 and TREM2 in M5 (immune-inflammatory processes, enriched in microglial cells) (Fig 7A). Here, TREM2 is linked to Alzheimer disease.