pSTAT1 and pSTAT3 levels clustered together across cells types including neutrophils, monocytes, CD4 T cells and CD8 T cells, suggesting that STAT1 and STAT3 phosphorylation levels may distinguish the normal cellular signaling pathways operative in healthy donors versus COVID-19 induced altered signaling pathways and subjects with COVID-19 (Fig 3). Here, STAT1 is linked to COVID-19.