ESR1 and cancer: Likewise, pathways in cancer (hsa05200) scored the second-lowest FDR of 1.34E-06 by modulating 15 genes (AKT1, ALK, AR, EDNRA, EGFR, ESR1, FGFR1, HGF, HSP90AA1, IL2RA, KIT, PGF, STAT1, TERT, and VEGFA).