The IL-10/TNF-α ratio was on average 30-fold (69.9 [12.5–140.7]), 10-fold (19.7 [1.6–115.2]), 6-fold (13.0 [3.5–24.9]) and 8-fold (16.9 [2.4–86.6]) higher in those with single or P. falciparum co-infections with filariae, STH and intestinal protozoa, respectively, than in uninfected participants. The gene discussed is TNF; the disease is coinfection.