Specifically, two small nuclear ribonucleoprotein U5 subunits (SNRNP40 and SNRNP200) and multiple splicing factors (e.g., HNRNP A0, A2B1, A3, DL, F, H1, H2, L, LL, R, U, UL1, UL2 and SRSF6) were significantly under-expressed in the COVID-19 patients (Fig 2B). The gene discussed is HNRNPA0; the disease is COVID-19.