We identified that 13 hnRNP proteins (HNRNP A0, A2B1, A3, DL, F, H1, H2, L, LL, R, U, UL1, and UL2) were down-regulated in our lung cases, suggesting that host splicing factors may act as a role to restrict viral replication in these fatal COVID-19 patients. Here, HNRNPC is linked to COVID-19.