Thus, in order to evaluate whether Six1 plays a pathophysiological role in lung fibrosis, we generated a tamoxifen-inducible conditional AT2-specific Six1-KO mouse (iAT2Six1–/–) using previously described SPC CreERT2 (27) and Six1-loxP/loxP mice (28). Here, SFTPC is linked to pulmonary fibrosis.