More importantly, recent studies in the BLM model of lung fibrosis revealed that treatment with an anti-MIF antibody showed decreased mortality, lung injury, and significantly lower inflammation but now lower collagen content at day 21, whereas mice treated with a small molecule, cell-permeable MIF antagonist (ISO-1) showed decreased fibrosis, collagen content, and vascular smooth muscle proliferation in BLM-treated mice compared with untreated controls (55, 56). Here, MIF is linked to pulmonary fibrosis.