Of note, the mRNA microarray analysis on lung tissues of mice identified that PTEN was significantly downregulated in mice with T2DM-PTB relative to those with T2DM before Mtb infection, and downregulation of PTEN was identified in the serum sample of patients with T2DM-PTB compared to those with T2DM only. Here, PTEN is linked to type 2 diabetes mellitus.