BRCA2 and Familial prostate cancer: Cumulative risk of prostate cancer for BRCA2 carriers was lower than that estimated in the UK and Ireland,37 probably because prostate cancer incidence rate is higher in European countries.35 Conversely, cumulative risk of gastric cancer was estimated at around 20% for both genes, which is likely higher than for European populations because of the higher incidence rate in East Asia countries.35 Taken together, the cumulative risk for each cancer type would be associated with the different incidence rate in each country.