POT1 mutations in the DNA-binding domain have been previously implicated as drivers of cancer (Robles-Espinoza et al., 2014; Calvete et al., 2017; Chen et al., 2017; Kim et al., 2021; Shen et al., 2020a; Shen et al., 2020b; Srivastava et al., 2020; Wu et al., 2020). Here, POT1 is linked to cancer.