Furthermore, immunofluorescence of HCMV-infected cells at 24 hpi showed enhanced ChREBP nuclear localization (Fig. 2B), indicating that, in response to HCMV infection, ChREBP translocates from the cytoplasm to the nucleus, where it normally acts as a transcription factor (29, –, 31). The gene discussed is MLXIPL; the disease is cytomegalovirus infection.