The upregulation of GBA2 in NP-C caused defects in sphingolipid targeting from ER to Golgi and lysosomal pH adjustment [146, 151–153], whereas the downregulation of GBA2 in PD was associated with synucleinopathy, which was closely related to autophagic dysfunction [150, 154]. This evidence concerns the gene GBA2 and Parkinson disease.