Our result strongly corroborated and supports that the downregulation of the ENTPD3 gene during the early developmental stage may lead to functional deficits and increased risks of diabetics or even cancer in later life (Li et al., 2019), although, as per our observation, the level of gene expression did not correlate with the other important exposure conditions (e.g., DDT, DDE, HCH) (data not shown). This evidence concerns the gene ENTPD3 and diabetes mellitus.