In univariate analysis for disease‐free survival (DFS), male sex (p = 0.016), smoking history (p < 0.001), CEA (p = 0.003), SUVmax (p < 0.001), entire tumor size (p < 0.001), PTS (p = 0.015), poor differentiation (p < 0.001), MP predominant subtype (p < 0.001), solid predominant subtype (p < 0.001), VPI (p < 0.001), close margin (p = 0.008), LVI (p < 0.001), and negative downstage migration (p = 0.043) were significant. The gene discussed is CEACAM5; the disease is neoplasm.