We performed expression analysis of IFN‐I genes (IFN‐α, ‐β, and ‐ω) and two IFN‐stimulated genes (ISGs), ISG15 and ISG56, in COVID‐19 patients who were positive for anti‐IFN‐I NAB, in gender and age‐matched control patients negative for BAB to anti‐IFN‐I (n = 24) and gender and age‐matched healthy individuals (n = 19). This evidence concerns the gene IFNA1 and COVID-19.