ISG15 and COVID-19: We found that, compared to healthy individuals, COVID‐19 patients had a reduced gene expression of IFN‐β, IFN‐ω, and ISG15 in blood cells, independently of the presence of anti‐IFN‐I NAB (Fig. 3, Panels B, C, and D, p < 0.05 for all genes, using Mann‐Whitney test).