In contrast to gender, age, S100B, LDH, BRAF-status, high-tumor thickness, and stage of disease, low neutrophil/lymphocyte ratio at baseline [median 3.1 (1–9.7), associated criterion ≤ 3.1, AUC 0.70)] and reduced MMR protein expression were determined as the only parameters significantly associated with BOR (P = 0.0092 and P = 0.0033, respectively). Here, BRAF is linked to neoplasm.