Mutations in the GBA1 gene are the most common genetic risk factor for idiopathic PD (Rosenbloom et al., 2011; Sidransky et al., 2009), and patients with GBA1 mutations develop nigrostriatal degeneration and aSyn pathology similar to sporadic PD patients (Blandini et al., 2018; Goker-Alpan et al., 2010; Neumann et al., 2009). The gene discussed is GBA1; the disease is Parkinson disease.