Moreover, FLOT2 expression is positively correlated with the tumor stage and lymphatic metastasis, and it is found that the proliferation of kidney cancer and breast cancer cells can be effectively inhibited after interference with FLOT2 gene [10]; in addition, FLOT2 gene expression is closely related to the invasion and metastasis of gastric cancer [11]. This evidence concerns the gene FLOT2 and breast carcinoma.