APOE and systemic lupus erythematosus: Vasorelaxation in response to Ach is impaired in many models of SLE that have type I IFN as a major driver of disease, including ApoE−/− mice exposed to IFNα-expressing adenovirus (39), pristane or imiquimod-treated mice (23–25, 27, 28), NZB/NZW F1 mice (35, 37, 38), and NZM2328 mice (39).