CAMP signaling increases histone deacetylase 8 (HDAC8s) expression through the Epac–Rap1–Akt pathway leading to augmenting cisplatin-induced apoptosis (Park and Juhnn, 2017) and inhibits radiation-induced ATM phosphorylation promoting apoptosis in lung cancer (Cho et al., 2014). Here, ATM is linked to lung cancer.