Nitric oxide (NO) is the most representative endogenous relaxing factor, and Endothelin-1 (ET-1) is a strong vasoconstrictor found so far, which is related to inflammatory reactions In the process, monocyte infiltration is related, and it is a type of inflammatory cytokines with chemotactic function (7, 8), but the expression of the two in the serum of gestational diabetes patients is currently unclear. This evidence concerns the gene EDN1 and gestational diabetes.