(2) By regulating the expression of the LDL receptor and the activity of lipoprotein lipase on the surface of liver cells, the occurrence of hypothyroidism can interfere with the reverse transport process of cholesterol in liver epithelial cells by promoting the occurrence of oxidative stress disorder in vivo, and lead to the decrease of LDL receptor sensitivity, the decrease of the number and activity of the LDL receptor on the surface of liver cells, the decrease of LDL clearance and degradation, the accumulation of LDL, and the abnormality of serum lipid metabolism. The gene discussed is LDLR; the disease is hypothyroidism.