The multivariate Cox regression analysis showed that after adjusting for traditional cardiovascular risk factors [including age, sex, current/former smoking, hypertension, hyperlipidemia, diabetes, previous stroke, and previous MI and family history of coronary heart disease (CHD)], there was statistical significance between the high level of MPO and composite MACEs (Model 1: medium level vs. low level, HR: 2.2, 95%CI: 0.87–5.59, p = 0.096; high level vs. low level, HR: 4.13, 95%CI: 1.66–10.29, P = 0.002). This evidence concerns the gene MPO and diabetes mellitus.