One person with heterozygous COL4A4 variant reached KF at the age 55, while eGFR (estimated glomerular filtration rate, using CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration formula) <30 ml/min/1.73 m2 was revealed in 11% (2/18) of individuals with COL4A4 changes. Here, COL4A4 is linked to chronic kidney disease.