There is now accumulative evidence linking TBI to dementia (Fann et al., 2018; Gardner et al., 2018) and neurodegenerative diseases (DeKosky and Asken, 2017; Brett et al., 2021) that involves the gradual and chronic hyperphosphorylation, misfolding, and missorting of the microtubule-associated protein, tau. The gene discussed is MAPT; the disease is neurodegenerative disease.