FOXO1 and alcoholic liver diseases: In the research of alcoholic liver disease (ALD), Heo et al. denoted that alcohol reduced the expression of miR-148a in hepatocytes by decreasing the expression of forkhead box protein O1 (FOXO1), and then promoted TXNIP expression and the activation of NLRP3 inflammasomes, thereby stimulating hepatocytes pyroptosis (Heo et al., 2019).