CASP1 and familial dilated cardiomyopathy: In the exploration of diabetic cardiomyopathy (DCM), Yang et al. emphasized that hsa_circ_0076631, named caspase-1-associated circRNA (CACR), was significantly increased in the serum of diabetic patients, and the silencing of CACR could reduce caspase-1 expression by sponging miR-214-3p, thereby restraining inflammation and pyroptosis of cardiomyocytes (Yang F. et al., 2019).