LUM and neoplasm: Lumican, a matrix protein which have an anti-tumor role inhibiting immune scape or even reversing several metastatic features in cancer cells (Karamanou et al., 2020; Giatagana et al., 2021; Zang et al., 2021) was produced in all experimental conditions, but mainly by KO PC in presence of GB as CMA dependent anti-tumor protein (Figure 2F).